Cialix pressure gradient
they do develop an undulation of flow and so it's not what I would call
pulsatile because that's a loaded term but essentially they do interact so the
sicker of the heart the more the more mechanical work at the heart that the
pump will take over compared to a less thick heart I was I was interested
because you mentioned the other device which reduces preload and that didn't
seem to be effective and some work that we've done here in Oslo we believe that
it's the after load which is really the critical signal at least when it comes
to cardiomyocytes in terms of both compensation and decolonization so I
actually wonder if that might fit with what you're seeing yeah it's a great
question we have this same
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closed during diastole the pressure gradient separates so in fact the pump flow
is highest its peak flow is during systole when there's no gradient and it has
a nadir when there is a gradient so even though their continuous flow pumps by
being dependent on the trans valvular pump thought and in fact you know I went
back to Reed and ripps physiology concepts and the idea of load and acute load
especially because that pump the ECMO pump takes blood from the venous system
and it puts it into the arterial system thereby pressurizing the arterial tree
so in fact we were hoping in that study design that we would see a loss of
function gain of function using two different pumps but because these were
healthy swine with a right atrial pressure of two or three but actually these
pumps these pumps by draining all the blood out of the venous system even
though they're pressurizing the arterial system we didn't see that persistent
increase in after load because the pumps essentially lost all their preload but
this question of preload
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design mmm-hmm very good I should go over to the Q&A I'll just remind all
of our viewers that they can post their questions here in the question and
answer box the first one is from anonymous attendee who says amazing work thank
you it's good start next one says why is a TVP better than ECMO as both of them
on Lothal yeah so I think that's that's what we were just talking about is the
idea that both reduced stroke work through two very different mechanisms but
one thing I'll point out for the for the group is that remember the first paper
we published was using left atrial to femoral artery bypass so in fact
everything is the same they're the oxygenator and disorient the the tubing the
pump takes blood from the left atrium which is already oxygenated and puts it
back into the arterial tree now in that case we didn't need to put an
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